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Year Number of Results
1997 1
1999 1
2000 1
2002 1
2005 2
2006 1
2007 3
2008 1
2009 2
2013 1
2014 1
2015 2
2016 1
2019 2
2020 2
2021 4
2022 2
2023 2
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28 results

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Page 1
Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma.
Yokota T, Nakata T, Minami S, Inazawa J, Emi M. Yokota T, et al. J Hum Genet. 2000;45(1):6-11. doi: 10.1007/s100380050002. J Hum Genet. 2000. PMID: 10697956
We recently isolated a novel cDNA, designated ELKS, that was fused to RET cDNA in a papillary thyroid carcinoma. ...Analysis of the region immediately upstream of exon 1 showed that it was extremely rich in G/C nucleotides and contained multiple Sp-1 and AP2 binding sequen …
We recently isolated a novel cDNA, designated ELKS, that was fused to RET cDNA in a papillary thyroid carcinoma. ...Analysis of the r …
Clinicopathologic features of kinase fusion-related thyroid carcinomas: an integrative analysis with molecular characterization.
Chu YH, Wirth LJ, Farahani AA, Nosé V, Faquin WC, Dias-Santagata D, Sadow PM. Chu YH, et al. Mod Pathol. 2020 Dec;33(12):2458-2472. doi: 10.1038/s41379-020-0638-5. Epub 2020 Jul 31. Mod Pathol. 2020. PMID: 32737449 Free PMC article.
The discovery of actionable kinase gene rearrangements has revolutionized the therapeutic landscape of thyroid carcinomas. ...Characteristic histology with multinodular growth and prominent fibrosis, particularly when there is extensive lymphovascular spread, should trigge …
The discovery of actionable kinase gene rearrangements has revolutionized the therapeutic landscape of thyroid carcinomas. ...Charact …
Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma.
Nakata T, Yokota T, Emi M, Minami S. Nakata T, et al. Genes Chromosomes Cancer. 2002 Sep;35(1):30-7. doi: 10.1002/gcc.10095. Genes Chromosomes Cancer. 2002. PMID: 12203787
A novel gene, ELKS, whose 5' portion was fused to the RET gene, was found in a papillary thyroid carcinoma. ...These results indicate that the ELKS gene is alternatively spliced, and that every type of ELKS-RET chimeric protein having oli …
A novel gene, ELKS, whose 5' portion was fused to the RET gene, was found in a papillary thyroid carcinoma. ...These re …
Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma.
Nakata T, Kitamura Y, Shimizu K, Tanaka S, Fujimori M, Yokoyama S, Ito K, Emi M. Nakata T, et al. Genes Chromosomes Cancer. 1999 Jun;25(2):97-103. doi: 10.1002/(sici)1098-2264(199906)25:2<97::aid-gcc4>3.0.co;2-l. Genes Chromosomes Cancer. 1999. PMID: 10337992
In a papillary thyroid carcinoma, we identified a novel gene (ELKS), the 5' portion of which is fused to the RET gene by gene rearrangement due to the translocation t(10;12)(q11;p13). Subsequent cloning of the ELKS cDNA revealed that ELKS …
In a papillary thyroid carcinoma, we identified a novel gene (ELKS), the 5' portion of which is fused to the RET gene b …
Role of Liprins in the Regulation of Tumor Cell Motility and Invasion.
Chiaretti S, de Curtis I. Chiaretti S, et al. Curr Cancer Drug Targets. 2016;16(3):238-48. doi: 10.2174/156800961603160206124103. Curr Cancer Drug Targets. 2016. PMID: 26882029 Review.
The PPFIA1 gene is amplified in malignant tumors, including about 20% of breast cancers. ...In the cell liprin-alpha1 forms a complex with liprin-beta1, ERC1/ELKS and LL5 proteins, which localizes at the front of migrating cells and positively regulates lamel …
The PPFIA1 gene is amplified in malignant tumors, including about 20% of breast cancers. ...In the cell liprin-alpha1 forms a complex …
Novel fusion sarcomas including targetable NTRK and ALK.
Chen T, Wang Y, Goetz L, Corey Z, Dougher MC, Smith JD, Fox EJ, Freiberg AS, Flemming D, Fanburg-Smith JC. Chen T, et al. Ann Diagn Pathol. 2021 Oct;54:151800. doi: 10.1016/j.anndiagpath.2021.151800. Epub 2021 Jul 22. Ann Diagn Pathol. 2021. PMID: 34464935
A pathologic fracture necessitated emergency hemipelvectomy (NED) and 2) novel KANK1-NTRK2 sarcoma of bone and soft tissue with spindled pleomorphic to epithelioid features (AWD metastases). 3) Novel ERC1-ALK unaligned fusion, a low grade infiltrative deep soft tissue hand …
A pathologic fracture necessitated emergency hemipelvectomy (NED) and 2) novel KANK1-NTRK2 sarcoma of bone and soft tissue with spindled ple …
Frequent EGFR exon 20 insertion in the so-called peripheral-type squamous cell neoplasm of uncertain malignant potential: a variant of bronchiolar adenoma or under-recognised entity?
Zheng Q, Hou L, Shang G, Qi X, Zhang M, Jin Y, Wang Y, Xue Q, Wu C, Li Y. Zheng Q, et al. Histopathology. 2023 Aug;83(2):178-192. doi: 10.1111/his.14890. Epub 2023 Mar 2. Histopathology. 2023. PMID: 36864007
Genetically, driver mutations, including frequent EGFR exon 20 insertions, were found in PSCN-UMPs, while the KRAS mutation, BRAF mutation, and ERC1::RET fusion were detected in BAs. PSCN-UMPs also shared some alterations with BAs in mutational signatures, while copy numbe …
Genetically, driver mutations, including frequent EGFR exon 20 insertions, were found in PSCN-UMPs, while the KRAS mutation, BRAF mutation, …
Identification of RET fusions in a Chinese multicancer retrospective analysis by next-generation sequencing.
Shi M, Wang W, Zhang J, Li B, Lv D, Wang D, Wang S, Cheng D, Ma T. Shi M, et al. Cancer Sci. 2022 Jan;113(1):308-318. doi: 10.1111/cas.15181. Epub 2021 Nov 15. Cancer Sci. 2022. PMID: 34710947 Free PMC article.
Fusion of RET with different partner genes has been detected in papillary thyroid, lung, colorectal, pancreatic, and breast cancer. Approval of selpercatinib for treatment of lung and thyroid cancer with RET gene mutations or fusions calls for studies to explore RET …
Fusion of RET with different partner genes has been detected in papillary thyroid, lung, colorectal, pancreatic, and breast cancer. A …
The RET proto-oncogene: a molecular therapeutic target in thyroid cancer.
Kodama Y, Asai N, Kawai K, Jijiwa M, Murakumo Y, Ichihara M, Takahashi M. Kodama Y, et al. Cancer Sci. 2005 Mar;96(3):143-8. doi: 10.1111/j.1349-7006.2005.00023.x. Cancer Sci. 2005. PMID: 15771616 Free article. Review.
More than 10 rearranged forms of RET, referred to as RET/PTC 1-9, ELKS/RET and RFP/RET, have been cloned from sporadic and radiation-associated papillary thyroid carcinomas. ...To date, various kinds of therapeutic approaches have been developed for the treatment of RET-as …
More than 10 rearranged forms of RET, referred to as RET/PTC 1-9, ELKS/RET and RFP/RET, have been cloned from sporadic and radiation- …
The landscape of BRCA1 and BRCA2 large rearrangements in an international cohort of over 20 000 ovarian tumors identified using next-generation sequencing.
Jones MA, Timms KM, Hatcher S, Cogan ES, Comeaux MS, Perry M, Morris B, Swedlund B, Elks CE, Lao-Sirieix P, Dearden S, Egile C, Brown JS, Harrington EA, Hodgson D, Stern M, Slavin TP, Mancini-DiNardo D. Jones MA, et al. Genes Chromosomes Cancer. 2023 Oct;62(10):589-596. doi: 10.1002/gcc.23150. Epub 2023 May 24. Genes Chromosomes Cancer. 2023. PMID: 37222498
MyChoice CDx uses NGS dosage analysis to detect LRs in BRCA1/BRCA2 genes using dense tiling throughout the coding regions and limited flanking regions. ...This study identified 84 unique LRs, 2 samples each carried 2 unique LRs in the same gene. We identified 17 LRs …
MyChoice CDx uses NGS dosage analysis to detect LRs in BRCA1/BRCA2 genes using dense tiling throughout the coding regions and limited …
28 results